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January 1, 2002Clinical and Experimental Hypertension

Does Sodium Sensitivity Affect Nocturnal Blood Pressure Variation in Outpatients With Hypertension?

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Why the study?

Does a low salt diet affect nocturnal blood pressure variation in outpatients with hypertension?

Population

20 outpatients with hypertension

Comparison

Low salt diet for a period of 1 or 2 weeks vs Regular sodium diet for a period of 2 weeks

Design

Cohort

Follow-up

3 to 4 weeks (2 weeks regular diet, 1-2 weeks low salt diet)

Authors

YWYasuo WatanabeYokohama University of PharmacyHNHideki NishimuraNagano Municipal HospitalSSSirish SanakaVidant Medical Center

Discussion

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Implication

May support sodium restriction to improve nocturnal BP dipping in hypertension; leaves open need for RCTs to confirm outcomes.

Structured PICO

Does a low salt diet affect nocturnal blood pressure variation in outpatients with hypertension?

P
Population
20 outpatients with hypertension
I
Intervention
Low salt diet (7 g/day) for a period of 1 or 2 weeks
C
Comparator
Regular sodium diet for a period of 2 weeks (pre-intervention baseline)
O
Outcome
Diurnal variation of blood pressure (nocturnal fall in blood pressure / dipper status) measured by 24-hour ambulatory blood pressure monitoringsurrogate

Sodium restriction can improve nocturnal blood pressure dipping patterns in hypertensive outpatients, though the non-dipper pattern is not universally reversed.

Cite This Study

Watanabe et al. (2002) studied this question.

synapsesocial.com/papers/6a7c5f1fa2188deaa4c299c7https://doi.org/10.1081/ceh-100108720

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NORMALIZATION OF CIRCADIAN BLOOD PRESSURE PROFILES AFTER RENAL TRANSPLANTATION1995 · 70 citations
  2. 2Sodium Restriction Shifts Circadian Rhythm of Blood Pressure From Nondipper to Dipper in Essential Hypertension1997 · 409 citations
  3. 3Diuretics Shift Circadian Rhythm of Blood Pressure From Nondipper to Dipper in Essential Hypertension1999 · 256 citations
  4. 4Salt sensitivity in hypertension. Renal and cardiovascular implications.1994 · 348 citations
  5. 5Intersalt revisited: further analyses of 24 hour sodium excretion and blood pressure within and across populations1996 · 862 citations