Key result
A 24-hour ambulatory blood pressure monitoring risk classification identified sodium sensitivity, with prevalence increasing from 25% in low-risk to 70% in high-risk hypertensive patients.
Why the study?
Does 24-hour ambulatory blood pressure monitoring accurately predict sodium sensitivity in mild to moderate hypertensive patients compared to traditional testing?
Observational (n=46)
Does 24-hour ambulatory blood pressure monitoring accurately predict sodium sensitivity in mild to moderate hypertensive patients compared to traditional testing?
24-hour ambulatory blood pressure monitoring may provide a simpler, reliable alternative to traditional testing for identifying sodium sensitivity in hypertensive patients.
Answers are grounded in this paper and cite their sources.
ABPM risk classification was associated with sodium sensitivity prevalence; leaves open whether it can replace traditional testing.
Sodium sensitivity is an important cardiovascular risk factor for which a diagnosis requires a time-consuming protocol, the implementation of which is often challenging for patients and physicians. Our aim was to assess the reliability of an easier approach based on data from 24-hour ambulatory blood pressure monitoring performed in hypertensive subjects during daily-life conditions and habitual diet. We enrolled 46 mild to moderate hypertensive subjects who underwent 24-hour ambulatory blood pressure monitoring during usual sodium intake. Patients were divided into 3 classes of sodium sensitivity risk on the basis of ambulatory blood pressure monitoring data: low risk if dippers and a 24-hour heart rate ≤ 70 bpm; high risk if nondippers and a 24-hour heart rate of > 70 bpm; intermediate risk with the remaining combinations (dippers with heart rate > 70 bpm or nondippers with heart rate ≤ 70 bpm). Then patients underwent a traditional sodium sensitivity test for the dichotomous classification as sodium sensitive or sodium resistant and for evaluating the sodium sensitivity index. Prevalence of sodium-sensitive patients and mean value of sodium sensitivity index were calculated in the 3 risk classes. The sodium sensitivity index markedly and significantly increased from the low-risk to the high-risk class, being equal to 19.9 ± 14.4, 37.8 ± 8.3, and 68.3 ± 17.0 mm Hg/(mol/day) in the low-risk, intermediate-risk, and high-risk classes, respectively (M ± SEM). Also, the prevalence of sodium-sensitive patients increased significantly from the low-risk class (25%) to the intermediate-risk (40%) and high-risk (70%) classes. Thus, performance of 24-hour ambulatory blood pressure monitoring in daily-life conditions and habitual diet may give useful information on the sodium sensitivity condition of hypertensive subjects in an easier manner than with the traditional sodium sensitivity test approach.
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Castiglioni et al. (2011) conducted an observational in Mild to moderate hypertension (n=46). 24-hour ambulatory blood pressure monitoring risk classification vs. Traditional sodium sensitivity test was evaluated on Prevalence of sodium-sensitive patients. A 24-hour ambulatory blood pressure monitoring risk classification identified sodium sensitivity, with prevalence increasing from 25% in low-risk to 70% in high-risk hypertensive patients.
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