Key result
Alamandine treatment for 14 days attenuated the development of fibrosis, reduced respiratory system elastance, and preserved weight gain in a rat model of bleomycin-induced pulmonary fibrosis.
Why the study?
Pulmonary fibrosis has limited treatment options, and reduced alamandine levels in idiopathic pulmonary fibrosis suggest it may be a therapeutic target.
Does alamandine alleviate pulmonary fibrosis and improve respiratory mechanics in a bleomycin-induced rat model?
Population
Wistar rats with bleomycin-induced pulmonary fibrosis
Comparison
Alamandine treatment for 14 days vs untreated fibrotic animals
Design
Animal experimental study
Follow-up
14 days
Authors
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Should not yet inform clinical management of pulmonary fibrosis; extends preclinical evidence and warrants human trials.
Does alamandine alleviate pulmonary fibrosis and improve respiratory mechanics in a bleomycin-induced rat model?
Alamandine shows potential as an antifibrotic therapy by alleviating pulmonary fibrosis and improving respiratory mechanics in a preclinical rodent model.
Fernandes et al. (2021) studied Pulmonary fibrosis. Alamandine (ALA) vs. Untreated fibrotic animals was evaluated on Development of fibrosis, respiratory system elastance, and weight gain. Alamandine treatment for 14 days attenuated the development of fibrosis, reduced respiratory system elastance, and preserved weight gain in a rat model of bleomycin-induced pulmonary fibrosis.
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