Why the study?
Does coronary artery ligation alter the susceptibility to atrial fibrillation in vivo and autonomic-mediated triggered arrhythmias in isolated pulmonary veins in dogs?
Population
Normal dogs and dogs studied 24 hours post-coronary artery ligation for in vivo studies, and isolated…
Comparison
Coronary artery ligation and subsequent testing… vs Normal dogs (no coronary artery ligation).
Design
Preclinical
Follow-up
24 hours post-ligation
Authors
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Post-MI AF inducibility rises in dogs despite reduced PV triggered activity; hypothesis-generating for non-PV mechanisms in clinical translation.
Does coronary artery ligation alter the susceptibility to atrial fibrillation in vivo and autonomic-mediated triggered arrhythmias in isolated pulmonary veins in dogs?
Despite increased in vivo susceptibility to atrial fibrillation post-myocardial infarction, isolated pulmonary veins show decreased susceptibility to autonomic-mediated triggered arrhythmias, associated with beta-adrenergic receptor desensitization.
Patterson et al. (2006) studied this question.
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