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July 22, 2003Circulation ResearchOpen Access

Beneficial Effects of Trimetazidine in Ex Vivo Working Ischemic Hearts Are Due to a Stimulation of Glucose Oxidation Secondary to Inhibition of Long-Chain 3-Ketoacyl Coenzyme A Thiolase

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Why the study?

Does trimetazidine improve functional recovery and cardiac efficiency in isolated working ischemic hearts?

Population

Isolated working hearts perfused with high levels of fatty acids subjected to a 30-minute period of global…

Design

Preclinical

Authors

GLGary D. LopaschukRBRick L. BarrPTPanakkezhum D. Thomas

Discussion

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Overview

May enhance post-ischemic efficiency in experimental hearts; leaves open clinical translation.

Structured PICO

Does trimetazidine improve functional recovery and cardiac efficiency in isolated working ischemic hearts?

P
Population
Isolated working hearts perfused with high levels of fatty acids subjected to a 30-minute period of global no-flow ischemia
I
Intervention
Trimetazidine (100 micromol/L)
O
Outcome
Functional recovery and cardiac efficiency after ischemiasurrogate

Trimetazidine improves cardiac function and efficiency after ischemia by inhibiting LC 3-KAT, which decreases fatty acid oxidation and stimulates glucose oxidation.

Cite This Study

Lopaschuk et al. (2003) studied this question.

synapsesocial.com/papers/6a7c6dbc24f98b6d3fc2d3d4https://doi.org/10.1161/01.res.0000086964.07404.a5
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