Why the study?
Does intravenous d-propranolol affect haemodynamics in patients with acute myocardial infarction?
Does intravenous d-propranolol affect haemodynamics in patients with acute myocardial infarction?
d-Propranolol does not significantly alter heart rate or systemic pressure in acute myocardial infarction, suggesting it is better tolerated than dl-propranolol and warrants further study as an anti-dysrhythmic agent.
Intravenous injections of 20-25 mg. d-propranolol did not change the heart rate or systemic pressure in 13 patients with cardiac infarction. Cardiac output was depressed in 10, but there was no clinical deterioration. d-Propranolol was better tolerated than dl-propranolol under these conditions and justifies further investigation as an anti-dysrhythmic agent. The major depressant effects of dl-propranolol following cardiac infarction appear to be due to beta-adrenergic blockade and not to a direct depressant action on cardiac muscle.
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Bennet et al. (1970) studied this question.
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