Why the study?
Does intravenous propranolol at low dosage (1 and 2 mg) cause significant haemodynamic depression in patients with acute myocardial infarction?
Does intravenous propranolol at low dosage (1 and 2 mg) cause significant haemodynamic depression in patients with acute myocardial infarction?
Intravenous propranolol at low doses of 1-2 mg produces antiarrhythmic effects with only negligible myocardial depression in patients with acute myocardial infarction.
Supports negligible depression with low-dose IV propranolol in acute MI; hypothesis-generating pending larger studies.
The haemodynamic effects of intravenous propranolol at low dosage (1 and 2 mg) have been evaluated on 14 patients in the acute stage of myocardial infarction. The first 1 mg propranolol was not followed by any significant variation in the variables measured. After the second 1 mg propranolol, the heart rate, cardiac index, and stroke index decreased significantly but moderately. Changes in pulmonary wedge pressure were not significant. It is concluded that intravenous propranolol in the small dosage of 1 or 2 mg, at which antiarrhythmic effect is still produced, has only a negligible depressant myocardial effect.
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Letac et al. (1975) studied this question.
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