Why the study?
Does nitric oxide mediate the inhibitory effect of losartan on angiotensin-induced contractions in rat and hamster aortas?
Population
Thoracic aorta rings from WKY rats, SHR rats, and hamsters (n=7 each)
Comparison
Losartan with or without L-NAME (10 M) or… vs Responses without L-NAME or indomethacin, and…
Design
Preclinical
Authors
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Species differences in NO mediation of losartan effects limit rodent-to-human translation; hypothesis-generating for ARB mechanisms.
Does nitric oxide mediate the inhibitory effect of losartan on angiotensin-induced contractions in rat and hamster aortas?
Basal secretion of nitric oxide is necessary for the full expression of the inhibitory effect of losartan on angiotensin-induced contractions in hamster aorta, but not in rat aorta.
Inoue et al. (2000) studied this question.
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