November 1, 1991Journal of Clinical InvestigationOpen Access

Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase. Thromboregulation by endothelial cells.

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Population

In vitro model using human umbilical vein endothelial cells and human platelets

Design

Preclinical

Authors

AMAaron J. MarcusCornell University LSL B SafierNewYork–Presbyterian Hospital KHKatherine A. HajjarCornell University

Discussion

Member takes

Implication

Endothelial ecto-ADPase may complement known antithrombotic pathways; animal data leave human relevance and targeting open.

Structured PICO

Population

In vitro model using human umbilical vein endothelial cells and human platelets

Intervention

Exposure of aspirin-treated platelets to aspirin-treated endothelial cells

Outcome

Platelet responsiveness and endothelial cell ADPase activitysurrogate

Human endothelial cells regulate platelet activation through an aspirin-insensitive ecto-ADPase, providing a complementary antithrombotic mechanism to prostacyclin and endothelium-derived relaxing factor.

Cite This Study

Marcus et al. (1991) studied this question.

synapsesocial.com/papers/6a7c90bf4fb5be70ed190488 https://doi.org/10.1172/jci115485

Topics

Dual antiplatelet therapy

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Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase. Thromboregulation by endothelial cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase. Thromboregulation by endothelial cells.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider