Key result
The intracellular renin-angiotensin system is an important local component, with alternative mechanisms of angiotensin II synthesis suggesting a need for novel therapeutic agents to block it.
Design
Review
Authors
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Supports preclinical rationale for intracellular RAS-targeted therapies; leaves open their clinical efficacy in cardiovascular disease.
The intracellular renin-angiotensin system plays a significant role in cardiovascular remodeling, suggesting a potential need for novel therapeutic agents to block it.
Kumar et al. (2008) conducted a review in Cardiovascular remodeling. Intracellular renin-angiotensin system was evaluated. The intracellular renin-angiotensin system is an important local component, with alternative mechanisms of angiotensin II synthesis suggesting a need for novel therapeutic agents to block it.
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