Population
Various cell types, particularly cardiac, renal, and vascular cells
Design
Review
Authors
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May warrant cell-specific RAS blockade in hyperglycemia; leaves open whether targeting intracellular Ang II improves outcomes.
Highlights the diversity of intracellular Ang II synthesis mechanisms across cell types, suggesting RAS blockade therapies should consider specific cellular and pathological contexts.
Kumar et al. (2008) studied this question.
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