Why the study?
The underlying mechanisms of the gut microbiome and fecal metabolome in heart failure have not been characterized.
Population
Dahl salt-sensitive rats
Comparison
Three groups including hypertensive heart failure rats
Design
Animal experimental study combining 16S rRNA gene sequencing and metabolomics
Key result
Hypertensive heart failure in rats induced by a high-salt diet significantly altered gut microbiome composition, including an increased Firmicutes to Bacteroidetes ratio, and changed 35 fecal metabolites.
Authors
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Dahl rat model links gut microbiome-metabolome to hypertensive HF; leaves open human translation and causality.
Li et al. (2021) studied Hypertensive heart failure (n=24). High-salt diet vs. Low-salt diet (0.3% NaCl) and salt-resistant rats on high-salt diet was evaluated on Changes in gut microbiome composition and fecal metabolomic profiles. Hypertensive heart failure in rats induced by a high-salt diet significantly altered gut microbiome composition, including an increased Firmicutes to Bacteroidetes ratio, and changed 35 fecal metabolites.