Rosenthal DI, Ganott MA, Wyshak G, Slovik DM, Doppelt SH, Neer RM. Quantitative computed tomography for spinal density measurement: factors affecting precision. Invest Radiol 1985;20: 306 — 310. Quantitative computed tomography (QCT) was performed in duplicate on 84 patients to test the short-term precision of the technique. Statistical analysis of the data revealed that precision was not a function of spinal density. It appeared to be worse in osteopenic individuals only when expressed as a percentage. Precision was slightly better in male than in female patients. There is a 90% likelihood that a duplicate measurement will fall within 20 CT units of the first determination in female patients and within ten units in male patients.
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Rosenthal et al. (1985) studied this question.