Key result
Individualized transfer functions did not significantly improve the reproduction of aortic pressure wave shape compared to generalized transfer functions in resting patients (RMSE 4.1 vs 4.4 mmHg).
Why the study?
Does an individualized transfer function improve the estimation of central aortic pressure from the peripheral pulse compared to a generalized transfer function in resting patients?
Cross-Sectional (n=50)
Does an individualized transfer function improve the estimation of central aortic pressure from the peripheral pulse compared to a generalized transfer function in resting patients?
Absolute Event Rate: 4.1% vs 4.4%
p-value: p=not significant
Individualization of the transfer function based on time delay does not significantly improve the estimation of central aortic pressure from peripheral pulse in resting patients compared to a generalized transfer function.
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Generalized transfer functions suffice for resting central pressure estimation; leaves open benefit of individualization in exercise or ambulatory settings.
Westerhof et al. (2008) conducted a cross-sectional in Patients at rest undergoing diagnostic angiography (n=50). Individualized transfer function (ITF) vs. Generalized transfer function (GTF) was evaluated on Root mean square error (RMSE) of reconstructed aortic pressure wave shape (p=not significant). Individualized transfer functions did not significantly improve the reproduction of aortic pressure wave shape compared to generalized transfer functions in resting patients (RMSE 4.1 vs 4.4 mmHg).
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