Why the study?
Does the ACE I/D polymorphism (DD genotype) increase the risk of ESRD or hypertension in patients with ADPKD compared to I-allele carriers?
Population
Patients with autosomal dominant polycystic kidney disease (ADPKD) from 13 studies
Comparison
ACE I/D polymorphism (DD genotype) vs I-allele carriers (ID+II genotypes)
Design
Meta-analysis
Authors
Loading...
ACE DD genotype does not modify ESRD or hypertension risk in ADPKD; confirms polymorphism is not a prognostic factor and should not guide management.
Does the ACE I/D polymorphism (DD genotype) increase the risk of ESRD or hypertension in patients with ADPKD compared to I-allele carriers?
The ACE I/D polymorphism (DD genotype) does not appear to be a significant modifier of renal deterioration or hypertension risk in patients with ADPKD.
Pereira et al. (2006) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: