What question did this study set out to answer?

To determine whether plasma asymmetric dimethylarginine and insulin resistance link impaired coronary flow reserve with peripheral endothelium-mediated vasodilation in patients with essential hypertension.

September 1, 2004American Journal of HypertensionOpen Access

Plasma asymmetric dimethylarginine and coronary and peripheral endothelial dysfunction in hypertensive patients

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Population

75 patients with essential hypertension and without coronary artery disease and diabetes mellitus

Design

Cross-sectional

Authors

STShin TakiuchiHigashi Takarazuka Satoh Hospital HFHideki FujiiKobe University Hospital KKKei KamidePreventive Cardiology

Discussion

Member takes

Implication

ADMA links coronary and peripheral endothelial dysfunction in hypertension; hypothesis-generating and requires prospective confirmation before clinical consideration.

Key Points

To determine whether plasma asymmetric dimethylarginine and insulin resistance link impaired coronary flow reserve with peripheral endothelium-mediated vasodilation in patients with essential hypertension.
Evaluated 75 hypertensive patients without coronary artery disease or diabetes (30 men, 45 women, mean age 61.5 ± 10.1 years).
Measured coronary flow reserve using adenosine-triphosphate stress transthoracic Doppler echocardiography and forearm endothelium-mediated vasodilation via venous occlusion strain gauge plethysmography.
Assessed plasma asymmetric dimethylarginine concentrations and performed 75-g oral glucose tolerance tests to evaluate insulin resistance.
Average coronary flow reserve was 2.54 ± 0.63 and forearm endothelium-mediated vasodilation was 86.0 ± 54.7%, showing a significant positive correlation between the two measures (r = 0.493, P < .001).
Coronary flow reserve and peripheral vasodilation significantly correlated with age and plasma asymmetric dimethylarginine, but showed no correlation with insulin resistance, plasma insulin, or left ventricular mass.
Multiple regression analysis identified plasma asymmetric dimethylarginine as the sole independent predictor associated with both coronary flow reserve and peripheral endothelial function.

Structured PICO

Population

75 patients with essential hypertension and without coronary artery disease and diabetes mellitus (30 men, 45 women, mean age 61.5 +/- 10.1 years)

Outcome

Correlation between coronary flow reserve (CFR) and endothelium-mediated vasodilation of the brachial artery (EMV-BA), and their association with plasma asymmetric dimethylarginine (ADMA) and insulin resistancesurrogate

Increased plasma ADMA is independently associated with both coronary and peripheral endothelial dysfunction in patients with essential hypertension.

Cite This Study

Takiuchi et al. (2004) studied this question.

synapsesocial.com/papers/6a7ca2f580d29ce2cbfab3cd https://doi.org/10.1016/j.amjhyper.2004.05.005

Topics

Hypertension management

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Implication

ADMA links coronary and peripheral endothelial dysfunction in hypertension; hypothesis-generating and requires prospective confirmation before clinical consideration.

Plasma asymmetric dimethylarginine and coronary and peripheral endothelial dysfunction in hypertensive patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Plasma asymmetric dimethylarginine and coronary and peripheral endothelial dysfunction in hypertensive patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider