What question did this study set out to answer?

To determine the effects of moderately prolonged endurance running on left ventricular systolic performance in healthy individuals.

March 1, 1991Journal of Applied Physiology

Prolonged exercise induces left ventricular dysfunction in healthy subjects

View Full Paper

Ask AI

Bookmark

Why the study?

Does prolonged exercise reduce left ventricular systolic performance in healthy male subjects?

Population

23 healthy male subjects, aged 18 to 51 years (mean 37 years).

Comparison

Prolonged exercise (a 20-km run). vs Brief exercise (treadmill) and rest.

Design

Cohort

Follow-up

Immediately on completion of exercise

Authors

JVJean‐Louis VanoverscheldeCardiac Imaging MYMustafa Z YounisUniversiti Putra Malaysia RVR. VanbutseleUCLouvain

Discussion

Member takes

Implication

May indicate transient post-exercise LV impairment in healthy subjects; this cohort evidence leaves open clinical relevance and need for validation.

Key Points

To determine the effects of moderately prolonged endurance running on left ventricular systolic performance in healthy individuals.
Enrolled 23 healthy male runners aged 18 to 51 years (mean 37 years) who completed both a brief treadmill run and a 20-km run on separate days.
Assessed cardiac function at rest and immediately post-exercise via M-mode, two-dimensional, and Doppler echocardiography, carotid pulse tracings, and end-systolic stress-shortening relationships.
Prolonged exercise significantly decreased left ventricular ejection fraction from 67 ± 5% to 60 ± 6% (P < 0.001) and rate-adjusted mean velocity of fiber shortening from 1.12 ± 0.2 to 0.91 ± 0.2 cm/s (P < 0.001).
Left ventricular end-diastolic volume declined from 147 ± 18 ml to 130 ± 23 ml (P < 0.01) and mean arterial pressure decreased from 99 ± 7 to 92 ± 8 mmHg (P < 0.001) following the 20-km run.
The end-systolic stress-shortening relationship was displaced downward after prolonged exercise (P < 0.05), demonstrating depressed contractile function independent of alterations in preload.

Structured PICO

Does prolonged exercise reduce left ventricular systolic performance in healthy male subjects?

Population

23 healthy male subjects, aged 18 to 51 years (mean 37 years).

Intervention

Prolonged exercise (a 20-km run).

Comparator

Brief exercise (treadmill) and rest.

Outcome

Left ventricular systolic function assessed by end-systolic stress-shortening relationships (ejection fraction and rate-adjusted mean velocity of fiber shortening) measured immediately on completion of exercise.surrogate

Moderately prolonged exercise induces a transient depression in left ventricular systolic performance in healthy subjects, independent of changes in preload.

Cite This Study

Vanoverschelde et al. (1991) studied this question.

synapsesocial.com/papers/6a7ca50d64c599404428a544 https://doi.org/10.1152/jappl.1991.70.3.1356

Topics

Echocardiography

View Full Paper

Ask AI

Bookmark

Implication

May indicate transient post-exercise LV impairment in healthy subjects; this cohort evidence leaves open clinical relevance and need for validation.

Prolonged exercise induces left ventricular dysfunction in healthy subjects

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Prolonged exercise induces left ventricular dysfunction in healthy subjects

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider