Population
Rat pulmonary resistance arteries from control rats and rats with pulmonary hypertension induced by two…
Comparison
Application of endothelin-1, sarafotoxin S6c… vs Age-matched control rat vessels and different…
Design
Preclinical
Authors
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Preclinical only; leaves open whether ET-1 hyperreactivity contributes to human hypoxic pulmonary hypertension.
In a rat model, chronic hypoxia-induced pulmonary hypertension increases endogenous vascular tone and potentiates contractile responses to endothelin-1, effects modulated by nitric oxide.
MacLean et al. (1998) studied this question.
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