Key result
Platelet membrane γ-glutamyl transferase activity >265 mU/mg was an independent predictor of major adverse cardiac events at 3 months in patients with acute coronary syndrome (P<0.05).
Why the study?
Does elevated platelet membrane γ-glutamyl transferase activity predict major adverse cardiac events in patients with acute coronary syndrome?
Observational (n=105)
Does elevated platelet membrane γ-glutamyl transferase activity predict major adverse cardiac events in patients with acute coronary syndrome?
p-value: p=<.05
Elevated platelet membrane γ-glutamyl transferase activity is an independent predictor of short-term major adverse cardiac events in patients with acute coronary syndrome.
No immediate change to ACS management; leaves open whether platelet GGT measurement improves risk stratification or outcomes.
γ-Glutamyl transferase (GGT) participates in oxidative and inflammatory reactions inside the atheroma plaque and platelets. We evaluated whether platelet membrane γ-glutamyl transferase (Plt-GGT) activity is a predictor of major adverse cardiac events (MACEs) during 3 months follow-up of patients with acute coronary syndrome (ACS; MACE-3M). We included 105 patients who were hospitalized consecutively with the diagnosis of ACS. Patients with an MACE-3M were older, more likely to have hypertension, hyperlipidemia, family history of coronary artery disease(CAD), thrombolysis in myocardial infarction (TIMI) risk score >4, higher Plt-GGT and serum GGT activities, serum C-reactive protein level, and lower left ventricular ejection fraction (LVEF) when compared to those without MACE-3M (all P values ≤.05). By receiver-operator characteristic (ROC) curve analysis, 265 mU/mg for Plt-GGT, 30 U/L for serum GGT, and 45% for LVEF were determined as cutoff values to discriminate MACEs. Platelet GGT activity >265 mU/mg, TIMI risk score >4, and family history of CAD were independent predictors of MACE-3M (all P values <.05). Platelet GGT activity was as an independent predictor for MACEs in patients with ACS during the 3 months follow-up.
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Demırtas et al. (2018) conducted an observational in Acute coronary syndrome (n=105). Platelet membrane γ-glutamyl transferase (Plt-GGT) activity vs. Lower Plt-GGT activity was evaluated on Major adverse cardiac events (MACEs) at 3 months (p=<.05). Platelet membrane γ-glutamyl transferase activity >265 mU/mg was an independent predictor of major adverse cardiac events at 3 months in patients with acute coronary syndrome (P<0.05).
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