Why the study?
Does the addition of vitamin E alone or in combination with vitamin C reduce doxorubicin-induced oxidative stress and cardiac damage in breast cancer patients?
Population
32 female patients with different stages of breast carcinoma and 10 healthy control subjects, age range…
Comparison
Vitamin E 800 IU/day alone or in combination… vs Doxorubicin alone 60 mg/M² every 21 days.
Design
RCT, randomized into 3 groups
Follow-up
42 days
Authors
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Supports adjunctive vitamins E+C with doxorubicin to lower cardiotoxicity biomarkers in breast cancer; extends RCT evidence for antioxidant cardioprotection.
Does the addition of vitamin E alone or in combination with vitamin C reduce doxorubicin-induced oxidative stress and cardiac damage in breast cancer patients?
Co-administration of antioxidant vitamins E and C with doxorubicin significantly reduces biomarker evidence of oxidative stress and cardiac cytotoxicity in breast cancer patients.
Kashkool et al. (2009) studied this question.
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