Key result
A one-unit increase in the triglyceride-glucose index was associated with an approximately 3-point increase in depression, anxiety, and stress scores among women with diagnosed hypertension.
Why the study?
The study aimed to investigate the association between the triglyceride-glucose index and emotional states, including depression, anxiety, and stress, in adults considering their blood pressure status.
Is the triglyceride-glucose index associated with emotional states in adults with different blood pressure statuses?
Cross-Sectional (n=5,379)
Is the triglyceride-glucose index associated with emotional states in adults with different blood pressure statuses?
The triglyceride-glucose index is significantly associated with worse emotional states (depression, anxiety, stress) specifically in women with diagnosed hypertension.
TyG index–emotional state links by BP status are hypothesis-generating; leaves open whether they predict outcomes or warrant intervention.
OBJECTIVES: This study aimed to investigate the association between the triglyceride-glucose (TyG) index and emotional states, including depression, anxiety, and stress, in adult men and women, considering their blood pressure (BP) status. METHODS: This cross-sectional study was conducted within the framework of the Tehran Lipid and Glucose Study, including 5379 adults (53.43% female). Participants were categorized into three groups based on their BP status: normotensive, suspected, and diagnosed hypertension. The TyG index was calculated, and emotional states were assessed using the Depression Anxiety Stress Scale-21 (DASS-21). Linear regression models were used to evaluate the mentioned association. RESULTS: Our findings showed a significant positive association between the TyG index and emotional states, including depression, anxiety, and stress, only in women with diagnosed hypertension. Specifically, a one-unit increase in the TyG index was associated with an approximately 3-point increase in the scores of depression ( β = 3.09, P = 0.007), anxiety ( β = 3.09, P = 0.009), and stress ( β = 3.09, P = 0.007). No significant associations were observed between the TyG index and emotional states in men or across other BP groups. CONCLUSION: The study highlights a stronger association between women's emotional well being and their metabolic health compared to men. Additionally, it underscores the critical importance of addressing emotional health in women with high TyG and diagnosed hypertension.
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Shirvani et al. (2025) conducted a cross-sectional in Hypertension and emotional states (n=5,379). Triglyceride-glucose (TyG) index was evaluated on Depression, anxiety, and stress scores (DASS-21) (β = 3.09, p=0.007). A one-unit increase in the triglyceride-glucose index was associated with an approximately 3-point increase in depression, anxiety, and stress scores among women with diagnosed hypertension.
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