Why the study?
Is the dopamine D1 receptor gene A-48G polymorphism associated with essential hypertension?
Population
131 Japanese subjects with essential hypertension (EH) and 136 age-matched normotensive (NT) controls
Comparison
Dopamine D1 receptor gene A-48G polymorphism vs Normotensive controls / Absence of G allele
Design
Case-control
Authors
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Supports possible genetic link to essential hypertension in Japanese patients; hypothesis-generating and should not change practice.
Is the dopamine D1 receptor gene A-48G polymorphism associated with essential hypertension?
The A-48G polymorphism in the dopamine D1 receptor gene is associated with essential hypertension and higher diastolic blood pressure in Japanese patients.
Sato et al. (2000) studied this question.
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