Key result
The DRD1 -48G allele was associated with lower diastolic BP at rest (P=0.032) and during stress (P=0.046), while the GNAS 393C allele was associated with higher systolic BP during stress.
Why the study?
Do DRD1 and GNAS gene polymorphisms influence blood pressure at rest and in response to behavioral stress in twin subjects?
Population
912 white and African American (44.5%) twin subjects, mean age 17.4 +/- 3.4 years
Comparison
A-48G polymorphism of the dopamine receptor type… vs Alternative alleles/genotypes
Design
Cross-sectional
Authors
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DRD1/GNAS variants were associated with BP responses to stress; hypothesis-generating for genetic influences on reactivity, needing prospective validation before any clinical role.
Observational (n=912)
Do DRD1 and GNAS gene polymorphisms influence blood pressure at rest and in response to behavioral stress in twin subjects?
p-value: p=0.032
DRD1 and GNAS gene polymorphisms are associated with blood pressure regulation at rest and during behavioral stress.
Lu et al. (2006) conducted an observational in Blood pressure regulation (n=912). A-48G polymorphism of the DRD1 gene and T393C polymorphism of the GNAS gene vs. Alternative alleles was evaluated on Systolic and diastolic blood pressure at rest and during stress tasks (p=0.032). The DRD1 -48G allele was associated with lower diastolic BP at rest (P=0.032) and during stress (P=0.046), while the GNAS 393C allele was associated with higher systolic BP during stress.
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