Key result
Multiple RAAS genetic modifications accounted for 2.5% and 7.3% of the total variance for systolic blood pressure levels at rest and during behavioral stress, respectively (P=0.003 to 0.009).
Why the study?
Do multiple RAAS genetic polymorphisms interact to affect blood pressure at rest and during behavioral stress in young normotensive subjects?
Population
920 young white and black twins (age: 12 to 30 years; 45% blacks), normotensive.
Design
Cross-sectional
Authors
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Associated with greater SBP variance during stress than rest in normotensives; leaves open predictive utility for incident hypertension.
Observational (n=920)
Do multiple RAAS genetic polymorphisms interact to affect blood pressure at rest and during behavioral stress in young normotensive subjects?
p-value: p=0.003 to 0.009
Multiple RAAS genetic modifications interact to contribute more to dynamic blood pressure regulation during behavioral stress than to static resting blood pressure.
Ge et al. (2006) conducted an observational in Normotensive (n=920). RAAS gene variants (polymorphisms) was evaluated on Variance of systolic blood pressure at rest and during stress (p=0.003 to 0.009). Multiple RAAS genetic modifications accounted for 2.5% and 7.3% of the total variance for systolic blood pressure levels at rest and during behavioral stress, respectively (P=0.003 to 0.009).
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