What question did this study set out to answer?

To review the mechanisms by which intrarenal dopamine interacts with natriuretic and antinatriuretic systems to control renal sodium metabolism and arterial blood pressure.

March 1, 2000Annual Review of Physiology

Intrarenal Dopamine: A Key Signal in the Interactive Regulation of Sodium Metabolism

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To review the mechanisms by which intrarenal dopamine interacts with natriuretic and antinatriuretic systems to control renal sodium metabolism and arterial blood pressure.
Synthesized molecular, experimental, and clinical evidence regarding dopamine synthesis from filtered L-DOPA in renal proximal tubule cells.
Analyzed downstream receptor signaling networks, cross-talk with angiotensin II and atrial natriuretic peptide, and direct modulation of tubular sodium transporters.
Intrarenal dopamine acts as a key natriuretic signal that directly inhibits Na+, K+ ATPase and other major tubule sodium transporters to promote sodium excretion during salt loading.
Impairment, genetic dysregulation, or downregulation of renal dopamine receptors attenuates the adaptive natriuretic response to high sodium intake and contributes to multigenetic hypertension.

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Implication

Narrative review reveals how intrarenal dopamine orchestrates renal sodium excretion across tubule segments, highlighting its causal role in multigenetic hypertension.

Cite This Study

Anita Aperia (2000) studied this question.

synapsesocial.com/papers/6a7ca78cc9ba99be288ce5c3 https://doi.org/10.1146/annurev.physiol.62.1.621

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Implication

Narrative review reveals how intrarenal dopamine orchestrates renal sodium excretion across tubule segments, highlighting its causal role in multigenetic hypertension.

Intrarenal Dopamine: A Key Signal in the Interactive Regulation of Sodium Metabolism

Key Points

Discussion

Implication

Cite This Study

Intrarenal Dopamine: A Key Signal in the Interactive Regulation of Sodium Metabolism

Key Points

Discussion

Implication

Cite This Study

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