Key result
Altered intrarenal dopamine signaling predisposes to salt-sensitive hypertension, dysregulates RAS, and contributes to CKD.
Why the study?
The intrarenal dopaminergic system's role in blood pressure regulation and its defects contributing to hypertension require further elucidation.
The intrarenal dopaminergic system is important in regulating blood pressure and renal function, with its dysfunction potentially underlying hypertension and kidney injury.
May identify dopamine pathway targets in salt-sensitive hypertension; leaves open whether modulation improves clinical outcomes.
PURPOSE OF REVIEW: This review will highlight recent findings concerning the regulation and signalling of the intrarenal dopaminergic system and the emerging evidence for its importance in blood pressure regulation. RECENT FINDINGS: There is an increasing evidence that the intrarenal dopaminergic system plays an important role in the regulation of blood pressure, and defects in dopamine signalling appear to be involved in the development of hypertension. Recent experimental models have definitively demonstrated that abnormalities in intrarenal dopamine production or receptor signalling can predispose to salt-sensitive hypertension and a dysregulated renin-angiotensin system. There are also new results indicating the importance of dopamine receptor mediated regulation of salt and water homeostasis along the nephron, and new studies indicating the role that the intrarenal dopaminergic system plays to mitigate the production of reactive oxygen species and progression of chronic renal disease. SUMMARY: New studies underscore the importance of the intrarenal dopaminergic system in the regulation of renal function and indicate how alterations in dopamine production or signalling may underlie the development of hypertension and kidney injury.
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Zhang et al. (2015) conducted a review in Hypertension. Intrarenal dopaminergic system was evaluated. Alterations in intrarenal dopamine production or receptor signaling predispose to salt-sensitive hypertension, dysregulate the renin-angiotensin system, and contribute to chronic renal disease.
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