What is the clinical evidence from this study?

Study design: Cross-Sectional. Population: Early mild diastolic heart failure (n=1764). Intervention: Increased brachial-ankle pulse wave velocity (baPWV) vs. Lower baPWV. Primary outcome: Early mild diastolic heart failure (p=<0.01).

What question did this study set out to answer?

To evaluate whether brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness, is independently associated with early mild diastolic heart failure in a general community population.

August 26, 2010European Heart JournalOpen Access

Relationship of arterial stiffness and early mild diastolic heart failure in general middle and aged population

Q: What are the key findings of this study?

Increased arterial stiffness (baPWV) was independently associated with early mild diastolic heart failure (median 1670.5 cm/s vs 1456.0 cm/s in non-DHF; P<0.01).

Q: What question did this study set out to answer?

To evaluate whether brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness, is independently associated with early mild diastolic heart failure in a general community population.

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Key result

Increased arterial stiffness (baPWV) was independently associated with early mild diastolic heart failure (median 1670.5 cm/s vs 1456.0 cm/s in non-DHF; P<0.01).

Why the study?

Is brachial-ankle pulse wave velocity associated with early mild diastolic heart failure in a general middle and aged population?

Population

1764 subjects from a general middle and aged population in the Lujiazui Community, Shanghai, including 482…

Design

Cross-sectional

Authors

SKSheng KangShanghai East Hospital HFHuimin FanTongji University JLJue LiSichuan University

Discussion

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Implication

baPWV may mark early mild DHF risk; hypothesis-generating, needs longitudinal studies before any screening role.

Key Points

To evaluate whether brachial-ankle pulse wave velocity (baPWV), an indicator of arterial stiffness, is independently associated with early mild diastolic heart failure in a general community population.
Screened 2095 community-dwelling individuals in Shanghai, analyzing 1764 participants with complete clinical data (482 with early mild diastolic heart failure and 1282 non-DHF controls).
Conducted morning evaluations after a 12-hour fast, measuring baPWV, echocardiographic indices, and serum brain natriuretic peptide.
Defined early mild diastolic heart failure as left ventricular ejection fraction >50%, mitral E/A ratio <0.8, and E/E' ratio ≤8.
baPWV was negatively correlated with the E/A ratio (r = -0.39, P < 0.01) and was significantly higher in subjects with early mild DHF than in non-DHF controls [median 1670.5 (IQR 1465.6–1910.8) vs. 1456.0 (IQR 1295.3–1698.3) cm/s, P < 0.01].
Multivariable logistic regression confirmed baPWV as an independent predictor of early mild DHF alongside age, male sex, BMI, ventricular wall thickness, left ventricular mass index, and both systolic (≥140 mmHg) and diastolic (≥90 mmHg) hypertension.

Study Design

Type

Cross-Sectional (n=1,764)

Multicenter

Structured PICO

Is brachial-ankle pulse wave velocity associated with early mild diastolic heart failure in a general middle and aged population?

Population

1,764 middle-aged and older adults (mean age 58.0, 68.4% female) from a general community population evaluated for the association between arterial stiffness and early mild diastolic heart failure.

Outcome

Association between brachial-ankle pulse wave velocity (baPWV) and early mild diastolic heart failuresurrogate

Main Result

p-value: p=<0.01

Increased arterial stiffness, measured by baPWV, is independently associated with early mild diastolic heart failure in a general middle-aged and elderly population.

Cite This Study

Kang et al. (2010) conducted a cross-sectional in Early mild diastolic heart failure (n=1,764). Increased brachial-ankle pulse wave velocity (baPWV) vs. Lower baPWV was evaluated on Early mild diastolic heart failure (p=<0.01). Increased arterial stiffness (baPWV) was independently associated with early mild diastolic heart failure (median 1670.5 cm/s vs 1456.0 cm/s in non-DHF; P<0.01).

synapsesocial.com/papers/6a7ca808041f7ddee0ba621e https://doi.org/10.1093/eurheartj/ehq296

Topics

Echocardiography

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Relationship of arterial stiffness and early mild diastolic heart failure in general middle and aged population

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Topics

Relationship of arterial stiffness and early mild diastolic heart failure in general middle and aged population

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

Also Consider