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March 6, 2018PLoS MedicineOpen Access

Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort

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Why the study?

Does the presence and specific phenotype of multimorbidity reduce long-term survival and life expectancy in patients with acute myocardial infarction?

Population

693,388 patients admitted with acute myocardial infarction between 1 January 2003 and 30 June 2013, median…

Comparison

High multimorbidity phenotype cluster and medium… vs Low multimorbidity phenotype cluster and general…

Design

Cohort

Follow-up

maximum 8.4 years (median 2.3 years)

Authors

MHMarlous HallTDTatendashe B DondoAYAndrew T. Yan

Discussion

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Overview

High multimorbidity clusters flag post-AMI patients for closer monitoring; leaves open whether phenotype-specific interventions improve survival.

Structured PICO

Does the presence and specific phenotype of multimorbidity reduce long-term survival and life expectancy in patients with acute myocardial infarction?

P
Population
693,388 patients admitted with acute myocardial infarction (AMI) between 1 January 2003 and 30 June 2013, median age 70.7 years, 65.5% male, from the Myocardial Ischaemia National Audit Project (England and Wales).
I
Intervention
High multimorbidity phenotype cluster (class 1: concomitant heart failure, peripheral vascular disease, and hypertension) and medium multimorbidity phenotype cluster (class 2: peripheral vascular disease and hypertension).
C
Comparator
Low multimorbidity phenotype cluster (class 3) and general age-, sex-, and year-matched population.
O
Outcome
All-cause mortality and loss in life expectancy over a maximum 8.4-year follow-up period.hard clinical

Multimorbidity is highly prevalent in AMI patients, and specific clusters (e.g., heart failure, peripheral vascular disease, and hypertension) are associated with a substantial loss in life expectancy, highlighting the need for comprehensive secondary prevention strategies.

Limitations

  • Limited to all-cause mortality due to the lack of available cause-specific mortality data
  • Other conditions including dementia and cancer were not included

Cite This Study

Hall et al. (2018) studied this question.

synapsesocial.com/papers/6a7caa04a42cae215d7cd132https://doi.org/10.1371/journal.pmed.1002501
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Also Consider

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