Population
Primary neuronal cultures from the hypothalamus/brainstem areas of 1-day-old normotensive and spontaneously…
Comparison
Infection with a retrovirus vector containing… vs Uninfected neuronal cultures or cultures…
Design
Preclinical
Authors
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Hypothesis-generating for brain AT1R antisense in hypertensive models; leaves open translation to human therapy.
Retroviral delivery of AT1R antisense selectively attenuates angiotensin II-mediated cellular actions in neuronal cultures from spontaneously hypertensive rats, demonstrating the potential for genetic manipulation of the brain renin-angiotensin system.
Lu et al. (1995) studied this question.
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