February 1, 1998AJP Heart and Circulatory Physiology

Attenuation of ANG II actions by adenovirus delivery of AT₁receptor antisense in neurons and SMC

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Population

Neuronal and vascular smooth muscle (VSM) cells

Comparison

Adenoviral vector transferring AT1 receptor… vs Uninfected cells or cells infected with…

Design

Preclinical

Follow-up

up to 28 days

Authors

DLDi LüRiddet Institute HYHong YangKunming Medical University MRMohan K. RaizadaPreventive Cardiology

Discussion

Member takes

Implication

Supports AT1R antisense gene therapy approach; leaves open in vivo validation and clinical translation for ANG-dependent hypertension.

Structured PICO

Population

Neuronal and vascular smooth muscle (VSM) cells

Intervention

Adenoviral vector transferring AT1 receptor antisense cDNA (Ad-AT1R-AS)

Comparator

Uninfected cells or cells infected with adenovirus particles containing a mutant AT1 receptor sense cDNA

Outcome

Attenuation of ANG II-mediated cellular actions (AT1 receptor protein levels, maximal binding, [3H]thymidine incorporation in VSM cells, and norepinephrine transporter gene expression in neuronal cells)surrogate

Adenovirus-mediated delivery of AT1 receptor antisense cDNA successfully attenuates ANG II cellular actions in neuronal and VSM cells, demonstrating proof-of-concept for a potential gene therapy approach in ANG-dependent hypertension.

Cite This Study

Lü et al. (1998) studied this question.

synapsesocial.com/papers/6a831a0a292d2964071f2b7e https://doi.org/10.1152/ajpheart.1998.274.2.h719

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Attenuation of ANG II actions by adenovirus delivery of AT₁receptor antisense in neurons and SMC

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Attenuation of ANG II actions by adenovirus delivery of AT₁receptor antisense in neurons and SMC

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider