Why the study?
Does the presence of normoblasts in peripheral blood indicate an unfavorable prognosis in patients with severe heart failure?
Does the presence of normoblasts in peripheral blood indicate an unfavorable prognosis in patients with severe heart failure?
The finding of normoblasts in the peripheral blood of patients with severe heart failure is a marker of severe hypoxemia and a very poor prognosis.
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Normoblasts were associated with grave prognosis in severe HF; hypothesis-generating for hypoxemia biomarker utility, pending prospective validation.
The authors recommend the search for normoblasts in the blood of patients with severe heart failure. When normoblasts are found, a marked interference with the oxygenation of the blood, either by pulmonary infarcts or thrombi inside the heart, is most likely to be present. It seems justifiable to consider the prognosis as very grave in these cases. This rule proved to hold even in those cases where, concomitant with an improvement in the heart failure, the normoblasts disappeared temporarily from the peripheral blood.
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Groen et al. (1948) studied this question.
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