Why the study?
Does injection of hyaluronic acid hydrogels with different degradation behaviors improve ventricular remodeling in an ovine model of myocardial infarction?
Does injection of hyaluronic acid hydrogels with different degradation behaviors improve ventricular remodeling in an ovine model of myocardial infarction?
Stable, non-degrading hyaluronic acid hydrogels provide longer mechanical stabilization and are more effective at maintaining left ventricular wall thickness and volume after myocardial infarction compared to degradable hydrogels.
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Stable hydrogels may better preserve post-MI wall thickness in sheep; hypothesis-generating for human biomaterial therapy, not ready for practice.
Tous et al. (2011) studied this question.
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