Why the study?
Does the sodium acetate in plasma protein fraction cause vasodilation in a canine right heart bypass model?
Does the sodium acetate in plasma protein fraction cause vasodilation in a canine right heart bypass model?
Acetate, widely used as a buffer in intravenous solutions like plasma protein fraction, is the primary cause of paradoxical vasodilation and hypotension, rather than bradykinin.
Acetate may drive vasodilation from plasma protein fraction in this model; hypothesis-generating for human hypotension and challenges bradykinin role.
Paradoxical hypotension during rapid infusion of plasma protein fraction (PPF) has been attributed to vasodilation by bradykinin in PPF. This study employed a canine, controlled right heart bypass preparation to assess changes in systemic vascular resistance and venous capacitance during infusion of PPF and other possibly vasoactive mediators. Plasma protein fraction caused consistent vasodilation, whereas purified human albumin did not. This vasodilation could be ascribed entirely to acetate, present in PPF as a buffer. Bradykinin in PPF had no effect during venous infusion. Acetate is used widely as a buffer in intravenous and dialysate solutions. Its vasoactive properties must be recognized when such solutions are administered to patients with limited capacity to compensate for sudden vasodilation.
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Olinger et al. (1979) studied this question.
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