Why the study?
Does 5% plasma protein fraction cause hypotension compared to 5% albumin in patients undergoing cardiopulmonary bypass?
Does 5% plasma protein fraction cause hypotension compared to 5% albumin in patients undergoing cardiopulmonary bypass?
Commercial 5% plasma protein fraction solutions can cause significant hypotension due to vasodilation, an effect not seen with 5% albumin.
May cause hypotension during CPB; hypothesis-generating and should not yet change practice versus albumin.
Hypotension exceeding 24% of mean arterial blood pressure, including one episode of complete circulatory collapse, occurred in two awake and eight anesthetized patients after infusion of 100 to 250 ml of 5% plasma protein fraction (PPF). To establish the cause of the hypotension, 50 ml of 5% albumin and of three preparations of 5% PPF was administered to 11 patients during constant-flow complete cardiopulmonary bypass, when changes in arterial pressure represent changes in systemic vascular resistance. No significant change occurred after administration of 5% albumin. A decrease, which exceeded the 99% confidence limit for 5% albumin, was observed in 3, 4, and 11 of 11 patients after the three preparations of 5% PPF.
No takes yet. Share an insight, caveat, or question.
J. H. Bland (1973) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: