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July 1, 2000The Journal of Clinical Endocrinology & MetabolismOpen Access

Subcutaneous Adipose Tissue Metabolism at Menopause: Importance of Body Fatness and Regional Fat Distribution1

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Why the study?

Does menopause per se influence subcutaneous adipose tissue metabolism when matched for body fatness and regional fat distribution?

Population

16 women classified by menopausal status: 8 postmenopausal and 8 premenopausal, matched for subcutaneous…

Comparison

Postmenopausal status vs Premenopausal status

Design

Cross-sectional

Authors

PMPascale MauriègePIPascal ImbeaultDPDaniel J. Prudhomme

Discussion

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Overview

No independent menopause effect on adipose lipolysis or LPL when fatness matched; supports body composition primacy and leaves open prospective confirmation.

Structured PICO

Does menopause per se influence subcutaneous adipose tissue metabolism when matched for body fatness and regional fat distribution?

P
Population
16 women classified by menopausal status: 8 postmenopausal (mean age 57 +/- 6 yr) and 8 premenopausal (mean age 37 +/- 5 yr), matched for subcutaneous abdominal adipose cell size and visceral adipose tissue accumulation.
I
Intervention
Postmenopausal status
C
Comparator
Premenopausal status
O
Outcome
Subcutaneous adipose tissue metabolism (lipoprotein lipase activities, fat cell lipolysis, and adrenoceptor sensitivity)surrogate

Menopause per se does not influence subcutaneous adipose tissue metabolism once variations related to adipose cell size and total body fatness are taken into account.

Cite This Study

Mauriège et al. (2000) studied this question.

synapsesocial.com/papers/6a7cb9f452489361ef8ce69dhttps://doi.org/10.1210/jcem.85.7.6687
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Changes in abdominal subcutaneous adipose tissue phenotype following menopause is associated with increased visceral fat mass2021 · 112 citations
  2. 2Dysregulation of subcutaneous adipose tissue blood flow in overweight postmenopausal women2010 · 19 citations
  3. 3New Insights on the Environment of Sex Steroids in Adipose Tissue of Postmenopausal Women at Hormone Therapy2024
  4. 4Age-related increase in visceral adipose tissue and body fat and the metabolic risk profile of premenopausal women.1999 · 193 citations
  5. 5Abdominal Obesity, Muscle Composition, and Insulin Resistance in Premenopausal Women2002 · 221 citations