Key result
Postmenopausal status was associated with a 123% greater visceral adipose tissue mass compared to premenopausal status, alongside adipocyte hypertrophy, inflammation, and fibrosis.
Why the study?
Menopause is associated with a redistribution of adipose tissue toward central adiposity, which is known to cause insulin resistance.
Does postmenopausal status alter adipose tissue phenotype and insulin resistance in women aged 45-60?
Population
33 women between 45 and 60 years
Comparison
Adipose tissue phenotype and distribution across menopause
Design
Cross-sectional study
Authors
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Menopause-linked adipose changes may worsen insulin resistance; hypothesis-generating cross-sectional data leave causality and interventions open.
Cross-Sectional (n=33)
No
Does postmenopausal status alter adipose tissue phenotype and insulin resistance in women aged 45-60?
Effect estimate: 123% increase (95% CI 16-231)
Absolute Event Rate: 1.21% vs 0.35%
p-value: p=0.01
Menopause is associated with adverse morphological and inflammatory changes in both subcutaneous and visceral adipose tissue, which correlate with increased visceral fat accumulation and decreased insulin sensitivity.
Abildgaard et al. (2021) conducted a cross-sectional in Menopause (n=33). Postmenopausal status vs. Premenopausal status was evaluated on Visceral adipose tissue (VAT) mass (123% increase, 95% CI 16-231, p=0.01). Postmenopausal status was associated with a 123% greater visceral adipose tissue mass compared to premenopausal status, alongside adipocyte hypertrophy, inflammation, and fibrosis.
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