Why the study?
Structural and dispositional changes in gap junctions can disrupt electrical pulse propagation, but their characteristics, localization, and clinical associations in hypertrophic cardiomyopathy required evaluation.
Population
62 patients with hypertrophic cardiomyopathy aged 18 to 61 years and 8 control subjects aged 25 to 54 years
Comparison
Patients with hypertrophic cardiomyopathy vs subjects without cardiovascular disease
Design
Case-control study
Authors
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Cx43 gap junction lateralization in HCM myocardium tracks disease severity; leaves open causal role in electromechanical uncoupling.
The redistribution of Cx43+ gap junctions to the lateral surfaces of cardiomyocytes in hypertrophic cardiomyopathy indicates cellular immaturity and may contribute to electromechanical uncoupling.
Т. V. Sukhacheva (2024) studied this question.
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