Multicentre evaluation of the diagnostic value of cardiac troponin T, CK-MB mass, and myoglobin for assessing patients with suspected acute coronary syndromes in routine clinical practice

1105 hospital admissions, median age 67 years (range 15-96 years, 63.7% male) with suspected acute coronary syndromes (72.3% of cases) or other non-specific symptoms where cardiac disease required exclusion (27.7%), across 43 hospitals in 13 countries.

Measurement of cardiac troponin T, myoglobin, and creatine kinase MB isoenzyme (CK-MB) mass in parallel with conventional diagnostic tests.

Conventional diagnostic tests (standard ECG changes and CK-MB mass exceeding 5.0 microg/l).

Diagnostic efficiency assessed by receiver operator characteristic (ROC) curve analysis.surrogate