Why the study?
Does experimental renal hypertension increase aldosterone biosynthesis in rats?
Population
Rats with different forms of experimental renal hypertension due to clamping of one renal artery
Comparison
Clamping of one renal artery with the other… vs Control animals
Design
Preclinical
Authors
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No immediate clinical implications for hypertension care; leaves open relevance of enhanced aldosterone biosynthesis to human renovascular hypertension.
Does experimental renal hypertension increase aldosterone biosynthesis in rats?
In rats with experimental renal hypertension, increases in aldosterone production correlate with increases in plasma renin activity but are independent of blood pressure changes.
Müller et al. (1969) studied this question.
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