June 1, 1975Acta Physiologica Scandinavica

Plasma Renin Activity and in vitro Synthesis of Aldosterone by the Adrenal Glands of Rats with Spontaneous, Renal, or Pinealectomy‐Induced Hypertension

View Full Paper

Ask AI

Bookmark

Population

Rats with experimental hypertension (pinealectomy-induced, renal, and spontaneous)

Comparison

Experimental induction of hypertension or… vs Control rats

Design

Preclinical

Follow-up

5 weeks after operations

Authors

HKHeikki KarppanenUniversity of Helsinki SLS LahovaaraUniversity of Helsinki PMPekka T. MännistöUniversity of Helsinki

Discussion

Member takes

Implication

Hypothesis-generating in rat hypertension models; leaves open relevance to human renin-aldosterone pathophysiology.

Structured PICO

Population

Rats with experimental hypertension (pinealectomy-induced, renal, and spontaneous)

Intervention

Experimental induction of hypertension (pinealectomy or renal operation) or spontaneous hypertension

Comparator

Control rats

Outcome

Plasma renin activity and in vitro synthesis of aldosterone by adrenal glandssurrogate

The renin-aldosterone system appears important in maintaining renal hypertension, whereas elevated renin in pinealectomy-induced hypertension likely reflects increased sympathetic activity.

Cite This Study

Karppanen et al. (1975) studied this question.

synapsesocial.com/papers/6a815f732bdcf510039cd80c https://doi.org/10.1111/j.1748-1716.1975.tb05878.x

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Plasma Renin Activity and in vitro Synthesis of Aldosterone by the Adrenal Glands of Rats with Spontaneous, Renal, or Pinealectomy‐Induced Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Plasma Renin Activity and in vitro Synthesis of Aldosterone by the Adrenal Glands of Rats with Spontaneous, Renal, or Pinealectomy‐Induced Hypertension

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider