What question did this study set out to answer?

To characterize antibiotic resistance and virulence profiles in clinical Salmonella enterica isolates and evaluate silver nanoparticles as an alternative antimicrobial strategy.

January 7, 2025AntibioticsOpen Access

Emerging Resistance and Virulence Patterns in Salmonella enterica: Insights into Silver Nanoparticles as an Antimicrobial Strategy

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Authors

IGIrina Gheorghe-BarbuUniversity of Bucharest IBIlda Czobor BarbuUniversity of Bucharest RDRareș-Ionuț DragomirUniversity of Bucharest

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Implication

Cross-sectional study demonstrates high antibiotic resistance and virulence gene prevalence in outpatient Salmonella isolates, highlighting silver nanoparticles as a potential therapeutic alternative.

Key Points

To characterize antibiotic resistance and virulence profiles in clinical Salmonella enterica isolates and evaluate silver nanoparticles as an alternative antimicrobial strategy.
Analyzed 309 community-acquired Salmonella isolates from Romanian outpatients (65.05% under 4 years of age) using MALDI-TOF mass spectrometry and MicroScan susceptibility testing.
Assessed phenotypic virulence factors and quantified biofilm formation in 96-well plates alongside PCR and whole-genome sequencing (n=19) to detect resistance and virulence genes.
Evaluated the antimicrobial efficacy of a silver nanoparticle colloidal solution (AgNPsol) against multidrug-resistant isolates.
Resistance to at least one antibiotic occurred in 27.86% of isolates, most frequently to tetracycline, ampicillin, and piperacillin, driven by genes such as tet(A) (59.52%), sul1 (44.83%), and blaTEM (16.18%).
Isolates frequently expressed soluble virulence factors including haemolysin (67%), aesculinase (65%), and gelatinase (62%), with 98.63% carrying the invA invasion gene.
Silver nanoparticles exhibited antimicrobial effectiveness against multidrug-resistant Salmonella isolates.

Cite This Study

Gheorghe-Barbu et al. (2025) studied this question.

synapsesocial.com/papers/6a7cc4b8e7df423ee14c7e1a https://doi.org/10.3390/antibiotics14010046

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Emerging Resistance and Virulence Patterns in Salmonella enterica: Insights into Silver Nanoparticles as an Antimicrobial Strategy

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Key Points

Cite This Study

Emerging Resistance and Virulence Patterns in Salmonella enterica: Insights into Silver Nanoparticles as an Antimicrobial Strategy

Discussion

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Implication

Key Points

Cite This Study

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