September 1, 1997Journal of Cardiovascular Electrophysiology
Tissue Magnesium Levels and the Arrhythmic Substrate in Humans
Why the study?
Does tissue magnesium level correlate with QT interval dispersion in patients with arrhythmic complaints?
Population
40 patients with arrhythmic complaints, including 28 who underwent programmed stimulation.
Design
Cross-sectional
Authors
Discussion
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Implication
Reduced tissue magnesium was associated with greater QT dispersion; hypothesis-generating for supplementation trials in arrhythmia patients.
Structured PICO
Does tissue magnesium level correlate with QT interval dispersion in patients with arrhythmic complaints?
P
Population
40 patients with arrhythmic complaints, including 28 who underwent programmed stimulation.
I
Intervention
Measurement of tissue magnesium levels in sublingual epithelium using X-ray dispersive analysis
O
Outcome
Correlation between sublingual epithelial magnesium level and QT interval dispersion on 12-lead surface ECGsurrogate
Reduced tissue magnesium stores correlate with increased QT dispersion, particularly in patients with poor left ventricular systolic function, suggesting a potential arrhythmic risk factor.
Cite This Study
Haigney et al. (1997) studied this question.