March 13, 2008Investigative Radiology

Left Ventricular Postmyocardial Infarction Remodeling Studied by Combining MR-Tagging With Delayed MR Contrast Enhancement

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Population

Pigs (n = 8) subjected to reperfused myocardial infarction

Design

Preclinical

Follow-up

8 weeks

Authors

NMNathan MewtonHeart Failure & Transplant PCPierre CroisilleCardiac Imaging OWO. WeberAnna Needs Neuroblastoma Answers

Discussion

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Implication

Scar imposes peri-infarct strain burden during porcine post-MI remodeling; hypothesis-generating and leaves open human translation.

Structured PICO

Population

Pigs (n = 8) subjected to reperfused myocardial infarction

Intervention

Magnetic resonance imaging (MRI) including tagged cine MRI combined with matched late enhancement data (Gadolinium-DOTA-enhanced IR-GRE) at 3 days and 8 weeks after infarction

Outcome

Regional circumferential shortening (Ecc) and principal strain L1 in the infarcted, peri-infarcted, and remote myocardium, and global LV functionsurrogate

Scarred myocardium imposes an additional functional burden to the peri-infarcted myocardium during post-MI remodeling, as demonstrated by combined MR-tagging and delayed enhancement in a porcine model.

Cite This Study

Mewton et al. (2008) studied this question.

synapsesocial.com/papers/6a7cc8a78a7077a9e43f7809 https://doi.org/10.1097/rli.0b013e318161613e

Topics

Cardiac MRI

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Bookmark

Left Ventricular Postmyocardial Infarction Remodeling Studied by Combining MR-Tagging With Delayed MR Contrast Enhancement

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Left Ventricular Postmyocardial Infarction Remodeling Studied by Combining MR-Tagging With Delayed MR Contrast Enhancement

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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Topics

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