Population
Wistar-Kyoto spontaneously hypertensive rats (as discussed from recent studies)
Design
Review
Authors
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Vascular wall thickening may precede hypertension; leaves open its causal role and need for prospective trials.
Structural alterations in blood vessels, such as wall thickening, may be pressure-independent and play an etiological role in the initiation of hypertension rather than just being a secondary adaptation.
Lee et al. (1985) studied this question.
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