Why the study?
Are vascular abnormalities a primary cause or secondary consequence of hypertension?
Population
Patients with essential hypertension and animal models (e.g., spontaneously hypertensive rat)
Design
Review
Authors
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May support vascular normalization as a long-term hypertension goal; leaves open whether it should guide primary therapy.
Are vascular abnormalities a primary cause or secondary consequence of hypertension?
Vascular structural abnormalities in hypertension are likely secondary adaptations but may contribute to morbidity, making their normalization a desirable long-term treatment goal.
Michael J. Mulvany (1991) studied this question.
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