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November 1, 1996Clinical and Experimental Pharmacology and Physiology

Peripheral Vasculature in Essential Hypertension *

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Population

Patients with essential hypertension

Design

Review

Authors

MMMichael J. MulvanyVascular / Pulmonary Vascular

Discussion

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Implication

May support ACE inhibitor selection for vascular structure in hypertension; hypothesis-generating and requires prospective outcome trials.

Structured PICO

P
Population
Patients with essential hypertension
I
Intervention
Angiotensin-converting enzyme inhibitor perindopril
O
Outcome
Normalization of resistance vessel structure (increasing lumen diameter and decreasing media:lumen ratio)surrogate

Normalization of resistance vessel structure in essential hypertension requires reverse remodelling, which can be achieved with ACE inhibitors like perindopril.

Cite This Study

Michael J. Mulvany (1996) studied this question.

synapsesocial.com/papers/6a88ecde9f05dd9930a2a8bahttps://doi.org/10.1111/j.1440-1681.1996.tb03034.x

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Structural Determinants of Vascular Resistance Properties in Hypertension2008 · 80 citations
  2. 2Blunted effects of endothelin upon small subcutaneous resistance arteries of mild essential hypertensive patients1992 · 108 citations
  3. 3Comparison of fast and slow pressor effects of angiotensin II in the conscious rat1981 · 96 citations
  4. 4I. On Certain Points in the Anatomy and Pathology of Bright's Disease of the Kidney. II. On the Influence of the Minute Blood-Vessels upon the Circulation1868 · 63 citations
  5. 5Effect of Antihypertensive Treatment on Small Arteries of Patients With Previously Untreated Essential Hypertension1995 · 300 citations