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January 1, 1992Journal of Cardiovascular Pharmacology

The Development and Regression of Vascular Hypertrophy

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Why the study?

Does antihypertensive therapy correct vascular structure in genetic hypertension?

Population

Humans with essential hypertension (EH) and spontaneous hypertension in rats (SHRs)

Design

Review

Authors

MMMichael J. MulvanyVascular / Pulmonary Vascular

Discussion

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Implication

Mean BP reduction may not normalize vascular structure; leaves open whether pulse pressure targeting improves outcomes in hypertension.

Structured PICO

Does antihypertensive therapy correct vascular structure in genetic hypertension?

P
Population
Humans with essential hypertension (EH) and spontaneous hypertension in rats (SHRs)
I
Intervention
Antihypertensive therapy
O
Outcome
Vascular structure correction (regression of vascular hypertrophy)surrogate

Normalization of pulse pressure, rather than just mean blood pressure, may be crucial for correcting vascular structure in hypertension to improve prognosis.

Cite This Study

Michael J. Mulvany (1992) studied this question.

synapsesocial.com/papers/6a975ed42855ae6cf374b042https://doi.org/10.1097/00005344-199219002-00006

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Resistance Vessel Structure1991 · 8 citations
  2. 2PERIPHERAL VASCULATURE IN ESSENTIAL HYPERTENSION *1996 · 15 citations
  3. 3MOLECULAR MECHANISMS OF VASCULAR HYPERTROPHY IN THE SPONTANEOUSLY HYPERTENSIVE RAT1995 · 17 citations
  4. 4Effects of antihypertensive treatment on small artery remodelling2009 · 113 citations
  5. 5Structure and Function of Peripheral Vascular Smooth Muscle In Hypertension1989 · 7 citations