Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 27, 2011StrokeOpen Access

Hypertension Impairs Vascular Reactivity in the Pediatric Brain

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does untreated hypertension impair cerebrovascular reactivity in children and adolescents?

Population

73 children and adolescents aged 7 to 20 years, including 64 patients categorized as hypertensive…

Comparison

Untreated hypertension vs Normotensive control subjects

Design

Cross-sectional

Authors

LWLinda J. WongMaimonides Medical CenterJKJuan C. KupfermanStanford UniversityFKFenella J. KirkhamGreat Ormond Street Hospital

Discussion

Loading...

Member takes

Implication

May indicate early cerebrovascular impairment in untreated hypertensive youth; leaves open whether treatment reverses reactivity or affects long-term outcomes.

Structured PICO

Does untreated hypertension impair cerebrovascular reactivity in children and adolescents?

P
Population
73 children and adolescents aged 7 to 20 years, including 64 patients categorized as hypertensive, prehypertensive, or white coat hypertensive based on 24-hour ambulatory blood pressure, and 9 normotensive control subjects.
I
Intervention
Untreated hypertension
C
Comparator
Normotensive control subjects
O
Outcome
Cerebrovascular reactivity during hypercapnia (quantified by time-averaged maximum mean cerebral blood flow velocity and end-tidal CO2 using transcranial Doppler)surrogate

Untreated hypertension in children and adolescents is associated with blunted cerebrovascular reactivity, suggesting early cerebral end-organ damage.

Cite This Study

Wong et al. (2011) studied this question.

synapsesocial.com/papers/6a7cc9aba42cae215d7cd8d2https://doi.org/10.1161/strokeaha.110.607606

Topics

Hypertension management
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Neuropsychological characteristics of adolescent boys differing in risk for high blood pressure2006 · 26 citations
  2. 2Autoregulation of Brain Circulation in Severe Arterial Hypertension1973 · 875 citations
  3. 3Learning and Attention Problems Among Children With Pediatric Primary Hypertension2010 · 85 citations
  4. 4Underdiagnosis of Hypertension in Children and Adolescents2007 · 824 citations
  5. 5Association of higher diastolic blood pressure levels with cognitive impairment2009 · 135 citations