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June 1, 1967Journal of VirologyOpen Access

Virus Aggregation as the Cause of the Non-neutralizable Persistent Fraction

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Population

Virus populations including echovirus type 4, poliovirus, reovirus, influenza virus, adenovirus…

Comparison

Filtration through membranes with a pore… vs Clarified suspensions by low-speed centrifugation

Design

Preclinical

Authors

CWCraig WallisUniversity of WorcesterJMJoseph L. MelnickStatens Serum Institut

Discussion

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Implication

May refine viral neutralization assay interpretation; leaves open relevance to animal pathogenesis or clinical applications.

Structured PICO

P
Population
Virus populations including echovirus type 4 (Pesascek and DuToit strains), poliovirus, reovirus, influenza virus, adenovirus, herpesvirus, and vaccinia virus
I
Intervention
Filtration through membranes with a pore diameter no larger than twice that of the virus to obtain monodispersed virus
C
Comparator
Clarified suspensions by low-speed centrifugation (unfiltered, aggregated virus)
O
Outcome
Neutralization by homologous antiserum and percentage of persistent fractionsurrogate

Demonstrates that the non-neutralizable persistent fraction of viruses is caused by viral aggregation, which can be eliminated by appropriate membrane filtration.

Cite This Study

Wallis et al. (1967) studied this question.

synapsesocial.com/papers/6a7cc9e70ee04b7d6bfab2b4https://doi.org/10.1128/jvi.1.3.478-488.1967
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characteristics of Echo 4 (Shropshire) Virus Isolated during Epidemic of Aseptic Meningitis1961 · 21 citations
  2. 2Concentration of Enteroviruses on Membrane Filters1967 · 142 citations
  3. 3Plaque Enhancement of Enteroviruses by Magnesium Chloride, Cysteine, and Pancreatin1966 · 33 citations
  4. 4POLIOMYELITIS VIRUSES IN TISSUE CULTURE1953 · 14 citations
  5. 5Early Stages of Virus-cell Interaction as Studied by Using Antibody1962 · 69 citations