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March 1, 1978Journal of General Virology

Aggregation of Enterovirus Small Plaque Variants and Polioviruses under Low Ionic Strength Conditions

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Population

Small plaque variants of Coxsackievirus type B3, Echovirus types 4 and 11, and various strains of poliovirus

Design

Preclinical

Authors

ATAtsuko TotsukaNational Institute of Infectious DiseasesKOK. OhtakiNational Institute of Infectious DiseasesITISAMU TAGAYAStatens Serum Institut

Discussion

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Implication

No immediate clinical implications for viral management; leaves open relevance of ionic effects to human infection or vaccine stability.

Structured PICO

P
Population
Small plaque variants of Coxsackievirus type B3, Echovirus types 4 and 11, and various strains of poliovirus (Type 1 Sabin, Mahoney; Type 2 Sabin, MEF1; Type 3 Sabin, Saukett, Suwa)
I
Intervention
Low ionic strength conditions, varying pH, and inclusion of salts or DEAE-dextran
O
Outcome
Virion aggregationsurrogate

This basic virology study demonstrates that enterovirus and poliovirus aggregation depends on ionic strength, pH, and specific viral strain characteristics.

Cite This Study

Totsuka et al. (1978) studied this question.

synapsesocial.com/papers/6a8973b3abe412682d92e481https://doi.org/10.1099/0022-1317-38-3-519
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Also Consider

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  4. 4Separation of Plaque-type Variants of Encephalomyocarditis Virus by Chromatography on Calcium Phosphate1967 · 8 citations
  5. 5Comparative Studies of Plaque Variants Derived From a Florida Strain of Venezuelan Equine Encephalomyelitis Virus1972 · 7 citations